Metabolite | Fungus | Role in pathogenesis |
β-(1,3)-glucan | Paracoccidioides brasiliensis Blastomyces dermatitidis Histoplasma capsulatum | Protection the fungi against digestive enzymes of the host phagocytes |
Mannitol | Cryptococcus neoformans | Protection the fungi against oxidative killing by host phagocytes |
Pullulan | Aureobasidium pullulans | Mediating adhesion and attachment on host cells |
Estrogen-binding proteins | Coccidioides immitis | Accelerate spherule maturation and endospore release |
Hem-binding proteins | Candida albicans | Enabling the fungus to utilize hemin and hemoglobin as iron sources. |
Agglutinin-like sequence (Als) proteins | C. albicans | Mediating adhesion on host cells |
Farnesol | C. albicans | Affect host immunity |
WI-1 protein | Blastomyces dermatitidis | Mediating adhesion on macrophages |
Glycoprotein (gp4) | P. brasiliensis | Mediating attachment on macrophages |
Glucuronoxylomannan (GXM) | C. neoformans Trichosporon beigelii | Immunosuppressive agent |